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Takshashila Blue Paper — A Framework for Governing Human Gene Editing in India

Download the Blue Paper in PDF [430 KB] This Blue Paper was prepared as a result of a roundtable discussion organised by the Takshashila Institution on 15 December 2017, based on the Discussion Document: A Framework for Governing Gene Editing. The discussion document developed an analytical framework to differentiate gene...

Takshashila Discussion Document — A Framework for Enabling Predictive Genomics to Improve Public Health in India

By Shambhavi Naik and Pavan Srinath Download the Discussion Document in PDF. Heritable genetic diseases, particularly rare diseases, contribute to a significant disease burden in India. In India’s urban areas, congenital malformations and genetic disorders are the third most common cause of mortality in newborns. Rare diseases by themselves are...

The scientific argument for marrying outside your caste

Bengaluru: As India becomes more globalised, there are intense deliberations in orthodox families on the merits of getting married within their own community. The obvious go-to-market strategy is to ask for family recommendations and visit websites tailored for the community. This is typically followed by patrika and gotra matching, and some family meetings. But as...

डीएनए हो सकती है भारत के स्वास्थ्य की चाबी

‘जीन कुंडली खोलेगी ज़िंदगी के राज’ – जनसत्ता में प्रकाशित इस लेख में दावा किया गया है की डीएनए संरचना विधेयक के कानून बनते ही देश में जीन कुंडली बनाने का रास्ता साफ़ हो जाएगा| लेकिन यह निष्कर्ष ठीक नहीं है| डीएनए विधेयक कानून से स्थापित होने वाला डेटाबेस और...

Genomics data banking could revolutionise healthcare, but comes with unmitigated risks

You read a brochure that promises to tell you what diseases you are likely to get in the next decade. Obviously you want to lead a longer, healthier life. So you send a cheek swab to the clinic and await test results. Thankfully, your reports are largely all-clear except a...

Takshashila Policy Advisory — Comments on the National Guidelines for Gene Therapy Product Development and Clinical Trials

Download the Advisory in PDF This policy advisory contains recommendations and comments in response to the draft National Guidelines for Gene Therapy Product Development and Clinical Trials released by the Indian Council of Medical Research (ICMR) in consultation with the Department of Biotechnology (DBT) and Central Drug Standards Control Organisation...

The gene of prejudice in gender determination

From impeding track stars like Caster Semenya and Dutee Chand to laws restricting bathroom access and a proposal in the US for genetic determination of sex, the issue of gender identity remains mired in controversy. Can there be a sensible and humane resolution to this debate? Or does this debate...

Should India move towards germline gene editing aka genetically modified babies?

Chinese researcher He Jiankui – who announced on YouTube in November that he successfully modified the genes of Lulu and Nana, healthy newborn twins – has taken mankind one step closer to becoming the superpower that can triumph even nature in selecting our own genes. Scientists worldwide are appalled at...

Chinese gene-edited baby row rekindles need for guidelines in India

The global scientific community has been outraged by Chinese scientist He Jiankui’s claim of creating the world’s first genetically modified baby using the gene-editing technique CRISPR-Cas9. The scientist claims that baby Lulu – who differs from previous recipients of gene therapies like Layla Richards1 – was born with a genetic modification and will...

Discussion Document — A Framework for Governing Gene Editing

By Madhav Chandavarkar, Anirudh Kanisetti, Shambhavi Naik, and Ajay Patri Download the Discussion Document in PDF [1.2 MB] Executive Summary Gene editing offers many benefits. They range from basic research that can enhance the scientific understanding of gene functions to practical applications like improved healthcare and agricultural production. At the...
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